Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses

BACKGROUND: Memantine has shown clinical utility in preventing radiation-induced cognitive impairment, but the mechanisms underlying its protective effects remain unknown. We hypothesized that abnormal glutamate signaling causes radiation-induced abnormalities in neuronal structure and that memantin...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Duman, Joseph G, Dinh, Jeffrey, Zhou, Wei, Cham, Henry, Mavratsas, Vasilis C, Pavešković, Matea, Mulherkar, Shalaka, McGovern, Susan L, Tolias, Kimberley F, Grosshans, David R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892158/
https://ncbi.nlm.nih.gov/pubmed/29112734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox203
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