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Anti-IL-10 mediated enhancement of anti-tumor efficacy of a dendritic-cell targeting MIP3α-gp100 vaccine in the B16F10 mouse melanoma model is dependent on type I interferons
The chemokine MIP3α (CCL20) binds to CCR6 on immature dendritic cells. Vaccines fusing MIP3α to gp100 have been shown to be effective in therapeutically reducing melanoma tumor burden and prolonging survival in a mouse model. Other studies have provided evidence that IL-10 neutralizing antibodies (α...
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| Publicado no: | J Immunother |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5891382/ https://ncbi.nlm.nih.gov/pubmed/29334492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000212 |
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