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Impact of stochastically generated heterogeneity in hazard rates on individually randomized vaccine efficacy trials

BACKGROUND/AIMS: Network structure and individuals’ level of exposure to a pathogen can impact results from efficacy evaluation studies of interventions against infectious diseases. Heterogeneity in infection risk can cause randomized groups to increasingly differ as a trial progresses and as more h...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: Kahn, Rebecca, Hitchings, Matt, Bellan, Steven, Lipsitch, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891371/
https://ncbi.nlm.nih.gov/pubmed/29374974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774517752671
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