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Competing Effects of Indirect Protection and Clustering on the Power of Cluster-Randomized Controlled Vaccine Trials

Power considerations for trials evaluating vaccines against infectious diseases are complicated by indirect protective effects of vaccination. While cluster-randomized controlled trials (cRCTs) are less statistically efficient than individually randomized controlled trials (iRCTs), a cRCT’s ability...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Epidemiol
Hauptverfasser: Hitchings, Matt D T, Lipsitch, Marc, Wang, Rui, Bellan, Steven E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070038/
https://ncbi.nlm.nih.gov/pubmed/29522080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kwy047
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