CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species

As an established anticancer drug, gemcitabine (GEM) is an effective systemic treatment for advanced pancreatic cancer (PC). However, little is known about the potential effectors that may modify tumour cell sensitivity towards GEM. Autophagy, as a physiological cellular mechanism, is involved in bo...

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Опубликовано в: :Mol Oncol
Главные авторы: Fu, Zhiping, Cheng, Xi, Kuang, Jie, Feng, Haoran, Chen, Lingxie, Liang, Juyong, Shen, Xiaonan, Yuen, Stanley, Peng, Chenghong, Shen, Baiyong, Jin, Zhijian, Qiu, Weihua
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891043/
https://ncbi.nlm.nih.gov/pubmed/29453806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12179
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