CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species

As an established anticancer drug, gemcitabine (GEM) is an effective systemic treatment for advanced pancreatic cancer (PC). However, little is known about the potential effectors that may modify tumour cell sensitivity towards GEM. Autophagy, as a physiological cellular mechanism, is involved in bo...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Fu, Zhiping, Cheng, Xi, Kuang, Jie, Feng, Haoran, Chen, Lingxie, Liang, Juyong, Shen, Xiaonan, Yuen, Stanley, Peng, Chenghong, Shen, Baiyong, Jin, Zhijian, Qiu, Weihua
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891043/
https://ncbi.nlm.nih.gov/pubmed/29453806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12179
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