Activation of TNF‐α/NF‐κB axis enhances CRL4B(DCAF) (11) E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells

Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4B(DCAF) (11) E3 ligase, which specifically ubiquitinates and degrades the cy...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Zhang, Caiguo, Chen, Bin, Jiang, Kaibiao, Lao, Lifeng, Shen, Hongxing, Chen, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891038/
https://ncbi.nlm.nih.gov/pubmed/29377600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12176
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