CRL4B(DCAF11) E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells

Cell cycle progression in mammals is strictly controlled by a number of cyclin-dependent kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in cancer cells. Our previous work revealed that Cullin 4B (CUL4B), a critical component of the Cullin4B-RING E3 ligase com...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Chen, Zhi, Wang, Kun, Hou, Canglong, Jiang, Kaibiao, Chen, Bin, Chen, Jianwei, Lao, Lifeng, Qian, Lie, Zhong, Guibin, Liu, Zude, Zhang, Caiguo, Shen, Hongxing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430835/
https://ncbi.nlm.nih.gov/pubmed/28446751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01344-9
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg