CRL4B(DCAF11) E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells

Cell cycle progression in mammals is strictly controlled by a number of cyclin-dependent kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in cancer cells. Our previous work revealed that Cullin 4B (CUL4B), a critical component of the Cullin4B-RING E3 ligase com...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chen, Zhi, Wang, Kun, Hou, Canglong, Jiang, Kaibiao, Chen, Bin, Chen, Jianwei, Lao, Lifeng, Qian, Lie, Zhong, Guibin, Liu, Zude, Zhang, Caiguo, Shen, Hongxing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430835/
https://ncbi.nlm.nih.gov/pubmed/28446751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01344-9
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker