Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration

Across phylogeny, glutamate (Glu) signaling plays a critical role in regulating neural excitability, thus supporting many complex behaviors. Perturbed synaptic and extrasynaptic Glu homeostasis in the human brain has been implicated in multiple neuropsychiatric and neurodegenerative disorders includ...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Gibson, Chelsea L., Balbona, Joseph T., Niedzwiecki, Ashlin, Rodriguez, Peter, Nguyen, Ken C. Q., Hall, David H., Blakely, Randy D.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891035/
https://ncbi.nlm.nih.gov/pubmed/29590100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007269
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