Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration

Across phylogeny, glutamate (Glu) signaling plays a critical role in regulating neural excitability, thus supporting many complex behaviors. Perturbed synaptic and extrasynaptic Glu homeostasis in the human brain has been implicated in multiple neuropsychiatric and neurodegenerative disorders includ...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Gibson, Chelsea L., Balbona, Joseph T., Niedzwiecki, Ashlin, Rodriguez, Peter, Nguyen, Ken C. Q., Hall, David H., Blakely, Randy D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891035/
https://ncbi.nlm.nih.gov/pubmed/29590100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007269
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