Global Untargeted Serum Metabolomic Analyses Nominate Metabolic Pathways Responsive to Loss of Expression of the Orphan Metallo β-Lactamase, MBLAC1

The C. elegans gene swip-10 encodes an orphan metallo β-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized to the en...

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Pubblicato in:Mol Omics
Autori principali: Gibson, Chelsea L., Codreanu, Simona G., Schrimpe-Rutledge, Alexandra C., Retzlaff, Cassandra L., Wright, Jane, Mortlock, Doug P., Sherrod, Stacy D., McLean, John A., Blakely, Randy D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015503/
https://ncbi.nlm.nih.gov/pubmed/29868674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7mo00022g
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