Tumor-Stroma IL-1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, And Poor Prognosis In Pancreatic Cancer

Targeting the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) holds promise to augment the effect of chemotherapy, but success in the clinic has thus far been limited. Preclinical mouse models suggest that near-depletion of cancer-associated fibroblasts (CAF) carries a risk of acceler...

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Dettagli Bibliografici
Pubblicato in:Cancer Res
Autori principali: Zhang, Daoxiang, Li, Lin, Jiang, Hongmei, Li, Qiong, Wang-Gillam, Andrea, Yu, Jinsheng, Head, Richard, Liu, Jingxia, Ruzinova, Marianna B., Lim, Kian-Huat
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890818/
https://ncbi.nlm.nih.gov/pubmed/29363544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1366
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