Tumor-Stroma IL-1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, And Poor Prognosis In Pancreatic Cancer

Targeting the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) holds promise to augment the effect of chemotherapy, but success in the clinic has thus far been limited. Preclinical mouse models suggest that near-depletion of cancer-associated fibroblasts (CAF) carries a risk of acceler...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Zhang, Daoxiang, Li, Lin, Jiang, Hongmei, Li, Qiong, Wang-Gillam, Andrea, Yu, Jinsheng, Head, Richard, Liu, Jingxia, Ruzinova, Marianna B., Lim, Kian-Huat
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890818/
https://ncbi.nlm.nih.gov/pubmed/29363544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1366
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