IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer

Aberrant activation of the NF-κB transcription factors underlies chemoresistance in various cancer types, including colorectal cancer (CRC). Targeting the activating mechanisms, particularly with inhibitors to the upstream IκB kinase (IKK) complex, is a promising strategy to augment the effect of ch...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Li, Qiong, Chen, Yali, Zhang, Daoxiang, Grossman, Julie, Li, Lin, Khurana, Namrata, Jiang, Hongmei, Grierson, Patrick M., Herndon, John, DeNardo, David G., Challen, Grant A., Liu, Jingxia, Ruzinova, Marianna B., Fields, Ryan C., Lim, Kian-Huat
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795411/
https://ncbi.nlm.nih.gov/pubmed/31527315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130867
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