Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study

BACKGROUND: Moxifloxacin is a second-line anti-TB drug that is useful in the treatment of drug-resistant TB. However, little is known about its target site pharmacokinetics. Lower drug concentrations at the infection site (i.e. in severe lung lesions including cavitary lesions) may lead to developme...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Heinrichs, M Tobias, Vashakidze, Sergo, Nikolaishvili, Ketino, Sabulua, Irina, Tukvadze, Nestani, Bablishvili, Nino, Gogishvili, Shota, Little, Brent P, Bernheim, Adam, Guarner, Jeannette, Peloquin, Charles A, Blumberg, Henry M, Derendorf, Hartmut, Kempker, Russell R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890684/
https://ncbi.nlm.nih.gov/pubmed/29186509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx421
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