Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

BACKGROUND: The pharmacokinetic/pharmacodynamic (PK/PD) relationship for polymyxin B against Klebsiella pneumoniae infections is not known. METHODS: Dose-fractionation studies with subcutaneous polymyxin B were conducted in neutropenic mice in which infection with three strains of K. pneumoniae had...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Landersdorfer, Cornelia B, Wang, Jiping, Wirth, Veronika, Chen, Ke, Kaye, Keith S, Tsuji, Brian T, Li, Jian, Nation, Roger L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890666/
https://ncbi.nlm.nih.gov/pubmed/29149294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx409
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