Pharmacokinetics and pharmacodynamics of ‘old’ polymyxins: what is new?

‘Old’ colistin and polymyxin B are increasingly used as last-line therapy against multidrug-resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. For intravenous administration, colistin is dosed as its inactive prodrug colistin methanesulfonate...

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Bibliografiske detaljer
Main Authors: Bergen, Phillip J., Landersdorfer, Cornelia B., Zhang, Jing, Zhao, Miao, Lee, Hee Ji, Nation, Roger L., Li, Jian
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477253/
https://ncbi.nlm.nih.gov/pubmed/22959816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diagmicrobio.2012.07.010
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