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Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine

BACKGROUND: The replacement of β,γ-pyrophosphate by β,γ-phosphonate moieties within the triphosphate chain of 5′-triphosphate nucleoside analogues was previously studied for various antiviral nucleoside analogues such as AZT and 2′,3′-dideoxynucleosides. Thus, it has been shown that these chemical m...

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Foilsithe in:Antivir Chem Chemother
Main Authors: Laux, Wolfgang HG, Priet, Stéphane, Alvarez, Karine, Peyrottes, Suzanne, Périgaud, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: SAGE Publications 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890543/
https://ncbi.nlm.nih.gov/pubmed/29436843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206618757636
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