Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine

BACKGROUND: The replacement of β,γ-pyrophosphate by β,γ-phosphonate moieties within the triphosphate chain of 5′-triphosphate nucleoside analogues was previously studied for various antiviral nucleoside analogues such as AZT and 2′,3′-dideoxynucleosides. Thus, it has been shown that these chemical m...

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Bibliografiska uppgifter
I publikationen:Antivir Chem Chemother
Huvudupphovsmän: Laux, Wolfgang HG, Priet, Stéphane, Alvarez, Karine, Peyrottes, Suzanne, Périgaud, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2018
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890543/
https://ncbi.nlm.nih.gov/pubmed/29436843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206618757636
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