Nanopore sequencing and assembly of a human genome with ultra-long reads

We report the sequencing and assembly of a reference genome for the human GM12878 Utah/Ceph cell line using the MinION (Oxford Nanopore Technologies) nanopore sequencer. 91.2 Gb of sequence data, representing ∼30× theoretical coverage, were produced. Reference-based alignment enabled detection of la...

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Pubblicato in:Nat Biotechnol
Autori principali: Jain, Miten, Koren, Sergey, Miga, Karen H, Quick, Josh, Rand, Arthur C, Sasani, Thomas A, Tyson, John R, Beggs, Andrew D, Dilthey, Alexander T, Fiddes, Ian T, Malla, Sunir, Marriott, Hannah, Nieto, Tom, O'Grady, Justin, Olsen, Hugh E, Pedersen, Brent S, Rhie, Arang, Richardson, Hollian, Quinlan, Aaron R, Snutch, Terrance P, Tee, Louise, Paten, Benedict, Phillippy, Adam M, Simpson, Jared T, Loman, Nicholas J, Loose, Matthew
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group US 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889714/
https://ncbi.nlm.nih.gov/pubmed/29431738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4060
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