Nanopore sequencing and assembly of a human genome with ultra-long reads

We report the sequencing and assembly of a reference genome for the human GM12878 Utah/Ceph cell line using the MinION (Oxford Nanopore Technologies) nanopore sequencer. 91.2 Gb of sequence data, representing ∼30× theoretical coverage, were produced. Reference-based alignment enabled detection of la...

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Veröffentlicht in:Nat Biotechnol
Hauptverfasser: Jain, Miten, Koren, Sergey, Miga, Karen H, Quick, Josh, Rand, Arthur C, Sasani, Thomas A, Tyson, John R, Beggs, Andrew D, Dilthey, Alexander T, Fiddes, Ian T, Malla, Sunir, Marriott, Hannah, Nieto, Tom, O'Grady, Justin, Olsen, Hugh E, Pedersen, Brent S, Rhie, Arang, Richardson, Hollian, Quinlan, Aaron R, Snutch, Terrance P, Tee, Louise, Paten, Benedict, Phillippy, Adam M, Simpson, Jared T, Loman, Nicholas J, Loose, Matthew
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group US 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889714/
https://ncbi.nlm.nih.gov/pubmed/29431738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4060
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