OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis

Immunotherapy's effect against hepatocellular carcinoma (HCC) is hampered by immunosuppressive mechanisms in the tumor microenvironment. We assessed the clinicopathologic and biologic relevance of OX40, a costimulatory molecular expressed by regulatory T cells (Tregs), in HCC. We analyzed the i...

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Bibliografiske detaljer
Udgivet i:	Oncoimmunology
Main Authors:	Xie, Kunlin, Xu, Lin, Wu, Hao, Liao, Haotian, Luo, Lin, Liao, Mingheng, Gong, Jianping, Deng, Yang, Yuan, Kefei, Wu, Hong, Zeng, Yong
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2018
Fag:	Original Research
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5889283/ https://ncbi.nlm.nih.gov/pubmed/29632718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1404214
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OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis

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