CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

We report that CD47 was upregulated in different EMT-activated human breast cancer cells versus epithelial MCF7 cells. Overexpression of SNAI1 or ZEB1 in epithelial MCF7 cells activated EMT and upregulated CD47 while siRNA-mediated targeting of SNAI1 or ZEB1 in mesenchymal MDA-MB-231 cells reversed...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Autores principales: Noman, Muhammad Zaeem, Van Moer, Kris, Marani, Vanessa, Gemmill, Robert M., Tranchevent, Léon-Charles, Azuaje, Francisco, Muller, Arnaud, Chouaib, Salem, Thiery, Jean Paul, Berchem, Guy, Janji, Bassam
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889210/
https://ncbi.nlm.nih.gov/pubmed/29632713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1345415
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