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STINGing the Tumor's immune evasion mechanism
In order to enhance the STING dependent type I interferon (IFN) response, we formulated cyclic dinucleotides (CDN) with cancer vaccines to develop STINGVAX. Interestingly, tumors from STINGVAX treated mice demonstrated dramatic PD-L1 upregulation. When combined with PD-1 blockade, STINGVAX induced r...
Tallennettuna:
| Julkaisussa: | Oncoimmunology |
|---|---|
| Päätekijä: | |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Taylor & Francis
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5889205/ https://ncbi.nlm.nih.gov/pubmed/29632707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1083673 |
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