Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions within hours. This dedifferentiation can be ameliorated when PHHs are cultured in sandwich configuration (2Dsw), particula...

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Publicat a:Toxicol Sci
Autors principals: Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, van Houdt, Jos, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Hepatic Sandwich Cultures Vs. Spheroids for Long-Term Toxicity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888952/
https://ncbi.nlm.nih.gov/pubmed/29329425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx289
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