Genomic dissection of enhancers uncovers principles of combinatorial regulation and cell type-specific wiring of enhancer–promoter contacts

Genomic binding of transcription factors, like the glucocorticoid receptor (GR), is linked to the regulation of genes. However, as we show here, GR binding is a poor predictor of GR-dependent gene regulation even when taking the 3D organization of the genome into account. To connect GR binding sites...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Thormann, Verena, Rothkegel, Maika C, Schöpflin, Robert, Glaser, Laura V, Djuric, Petar, Li, Na, Chung, Ho-Ryun, Schwahn, Kevin, Vingron, Martin, Meijsing, Sebastiaan H
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888794/
https://ncbi.nlm.nih.gov/pubmed/29385519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky051
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