An engineered RNA binding protein with improved splicing regulation

The muscleblind-like (MBNL) family of proteins are key developmental regulators of alternative splicing. Sequestration of MBNL proteins by expanded CUG/CCUG repeat RNA transcripts is a major pathogenic mechanism in the neuromuscular disorder myotonic dystrophy (DM). MBNL1 contains four zinc finger (...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hale, Melissa A, Richardson, Jared I, Day, Ryan C, McConnell, Ona L, Arboleda, Juan, Wang, Eric T, Berglund, J Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888374/
https://ncbi.nlm.nih.gov/pubmed/29309648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1304
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