F40. NEUREXIN-1α (NRNX1α) HYPOFUNCTION INDUCES SCHIZOPHRENIA-RELEVANT DEFICITS IN CEREBRAL METABOLISM, COGNITIVE PROCESSING SPEED AND COGNITIVE FLEXIBILITY

BACKGROUND: Heterozygous deletions in NEUREXIN-1 (NRXN1) substantially increase the risk of developing schizophrenia (SZ) (Rujescu et al., 2009. Hum Mol Genet 18(5):988–96). We currently have little understanding into the mechanisms by which NRXN1 impacts on the brain to increase the risk of develop...

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Detalhes bibliográficos
Publicado no:Schizophr Bull
Main Authors: Hughes, Rebecca, Whittingham-Dowd, Jayde, Bristow, Greg, Clapcote, Stephen, Broughton, Susan, Dawson, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887798/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sby017.571
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