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Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

Deletions in the neurexin-1α gene were identified in large-scale unbiased screens for copy-number variations in patients with autism or schizophrenia. To explore the underlying biology, we studied the electrophysiological and behavioral phenotype of mice lacking neurexin-1α. Hippocampal slice physio...

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Autori principali: Etherton, Mark R., Blaiss, Cory A., Powell, Craig M., Südhof, Thomas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764944/
https://ncbi.nlm.nih.gov/pubmed/19822762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910297106
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