43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA

BACKGROUND: A large number of clinical and preclinical studies suggest that dysfunction at synapses for the excitatory neurotransmitter glutamate may play a critical role in the pathophysiological changes that underlie each of the major symptom clusters observed in schizophrenia patients. Interestin...

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Veröffentlicht in:Schizophr Bull
Hauptverfasser: Conn, P Jeffrey, Yohn, Samantha, Stansley, Branden, Foster, Dan, Plumley, Hyekyung, Lindsley, Craig
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887675/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sby014.179
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