Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide

[Image: see text] Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings. Multilayered polyelectrolyte fi...

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Pubblicato in:ACS Appl Mater Interfaces
Autori principali: Winther, Anna K., Fejerskov, Betina, ter Meer, Marja, Jensen, Najah B.S., Dillion, Ross, Schaffer, Jeremy E., Chandrawati, Rona, Stevens, Molly M., Schultze Kool, Leo J., Simonsen, Ulf, Zelikin, Alexander N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887086/
https://ncbi.nlm.nih.gov/pubmed/29570264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsami.8b01658
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