A sensitive and selective ELISA methodology quantifies a demyelination marker in experimental and clinical samples

Sciatic nerve chronic constriction injury (CCI) in rodents produces nerve demyelination via proteolysis of myelin basic protein (MBP), the major component of myelin sheath. Proteolysis releases the cryptic MBP epitope, a demyelination marker, which is hidden in the native MBP fold. It has never been...

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Détails bibliographiques
Publié dans:J Immunol Methods
Auteurs principaux: Remacle, Albert G., Dolkas, Jennifer, Angert, Mila, Hullugundi, Swathi K., Chernov, Andrei V., Jones, R. Carter W., Shubayev, Veronica I., Strongin, Alex Y.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886741/
https://ncbi.nlm.nih.gov/pubmed/29428829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2018.02.002
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