A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens

Most cancer cells harbor multiple drivers whose epistasis and interactions with expression context clouds drug and drug combination sensitivity prediction. We constructed a mechanistic computational model that is context-tailored by omics data to capture regulation of stochastic proliferation and de...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Bouhaddou, Mehdi, Barrette, Anne Marie, Stern, Alan D., Koch, Rick J., DiStefano, Matthew S., Riesel, Eric A., Santos, Luis C., Tan, Annie L., Mertz, Alex E., Birtwistle, Marc R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886578/
https://ncbi.nlm.nih.gov/pubmed/29579036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005985
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