Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway

Duchenne muscular dystrophy (DMD) is a muscle wasting disease in which inflammation influences the severity of pathology. We found that the onset of muscle inflammation in the mdx mouse model of DMD coincides with large increases in expression of pro-inflammatory cytokines [tumor necrosis factor-α (...

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Udgivet i:Hum Mol Genet
Main Authors: Wehling-Henricks, Michelle, Welc, Steven S, Samengo, Guiseppina, Rinaldi, Chiara, Lindsey, Catherine, Wang, Ying, Lee, Jeongyoon, Kuro-O, Makoto, Tidball, James G
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886268/
https://ncbi.nlm.nih.gov/pubmed/29040534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx380
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