Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a lethal muscle disease involving progressive loss of muscle regenerative capacity and increased fibrosis. We tested whether epigenetic silencing of the klotho gene occurs in the mdx mouse model of DMD and whether klotho silencing is an important feature of the d...

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Publicado en:Hum Mol Genet
Autores principales: Wehling-Henricks, Michelle, Li, Zhenzhi, Lindsey, Catherine, Wang, Ying, Welc, Steven S., Ramos, Julian N., Khanlou, Négar, Kuro-o, Makoto, Tidball, James G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181628/
https://ncbi.nlm.nih.gov/pubmed/27154199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw111
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