Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a lethal muscle disease involving progressive loss of muscle regenerative capacity and increased fibrosis. We tested whether epigenetic silencing of the klotho gene occurs in the mdx mouse model of DMD and whether klotho silencing is an important feature of the d...

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Publicat a:Hum Mol Genet
Autors principals: Wehling-Henricks, Michelle, Li, Zhenzhi, Lindsey, Catherine, Wang, Ying, Welc, Steven S., Ramos, Julian N., Khanlou, Négar, Kuro-o, Makoto, Tidball, James G.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181628/
https://ncbi.nlm.nih.gov/pubmed/27154199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw111
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