Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology

Hereditary hemorrhagic telangiectasia (HHT) is a highly debilitating and life-threatening genetic vascular disorder arising from endothelial cell (EC) proliferation and hypervascularization, for which no cure exists. Because HHT is caused by loss-of-function mutations in bone morphogenetic protein 9...

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Detaylı Bibliyografya
Yayımlandı:Hum Mol Genet
Asıl Yazarlar: Ruiz, Santiago, Chandakkar, Pallavi, Zhao, Haitian, Papoin, Julien, Chatterjee, Prodyot K, Christen, Erica, Metz, Christine N, Blanc, Lionel, Campagne, Fabien, Marambaud, Philippe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886173/
https://ncbi.nlm.nih.gov/pubmed/28973643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx358
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