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Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model

Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality, characterized by progressive degeneration of spinal-cord motor neurons, leading to atrophy of skeletal muscles. However, accumulating evidence indicates that it is a multi-system disorder, particularly in its severe form...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Sheng, Lei, Wan, Bo, Feng, Pengchao, Sun, Junjie, Rigo, Frank, Bennett, C Frank, Akerman, Martin, Krainer, Adrian R, Hua, Yimin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886172/
https://ncbi.nlm.nih.gov/pubmed/29220503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx418
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