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Germline TP53 mutations result into a constitutive defect of p53 DNA binding and transcriptional response to DNA damage
Li-Fraumeni Syndrome (LFS) results from heterozygous germline mutations of TP53, encoding a key transcriptional factor activated in response to DNA damage. We have recently shown, from a large LFS series, that dominant-negative missense mutations are the most clinically severe and, thanks to a new p...
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Publicado no: | Hum Mol Genet |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886078/ https://ncbi.nlm.nih.gov/pubmed/28369373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx106 |
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