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Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

IMPORTANCE: Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD) and have been hypothesized to contribute to disease pathogenesis. However, it is unknown whether circadian changes occur during the presymptomatic phase of the disease. OBJECTIVE: To examine the associations betwee...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Musiek, Erik S., Bhimasani, Meghana, Zangrilli, Margaret A., Morris, John C., Holtzman, David M., Ju, Yo-El S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885197/
https://ncbi.nlm.nih.gov/pubmed/29379963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2017.4719
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