Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

IMPORTANCE: Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD) and have been hypothesized to contribute to disease pathogenesis. However, it is unknown whether circadian changes occur during the presymptomatic phase of the disease. OBJECTIVE: To examine the associations betwee...

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Опубликовано в: :JAMA Neurol
Главные авторы: Musiek, Erik S., Bhimasani, Meghana, Zangrilli, Margaret A., Morris, John C., Holtzman, David M., Ju, Yo-El S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Medical Association 2018
Предметы:
Original Investigation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885197/
https://ncbi.nlm.nih.gov/pubmed/29379963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2017.4719
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