In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduced the mos...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Vincent, Leah R., Kerr, Samuel R., Tan, Yang, Tomberg, Joshua, Raterman, Erica L., Dunning Hotopp, Julie C., Unemo, Magnus, Nicholas, Robert A., Jerse, Ann E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885032/
https://ncbi.nlm.nih.gov/pubmed/29615507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01905-17
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