In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduced the mos...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:mBio
Prif Awduron: Vincent, Leah R., Kerr, Samuel R., Tan, Yang, Tomberg, Joshua, Raterman, Erica L., Dunning Hotopp, Julie C., Unemo, Magnus, Nicholas, Robert A., Jerse, Ann E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885032/
https://ncbi.nlm.nih.gov/pubmed/29615507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01905-17
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