In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduced the mos...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:mBio
Autors principals: Vincent, Leah R., Kerr, Samuel R., Tan, Yang, Tomberg, Joshua, Raterman, Erica L., Dunning Hotopp, Julie C., Unemo, Magnus, Nicholas, Robert A., Jerse, Ann E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885032/
https://ncbi.nlm.nih.gov/pubmed/29615507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01905-17
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars