Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC

The prion-like seeding of misfolded α-synuclein (αSyn) involved in the pathogenesis of Lewy body diseases (LBD) remains poorly understood at the molecular level. Using the real-time quaking-induced conversion (RT-QUIC) seeding assay, we investigated whether brain tissues from cases of dementia with...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Sano, Kazunori, Atarashi, Ryuichiro, Satoh, Katsuya, Ishibashi, Daisuke, Nakagaki, Takehiro, Iwasaki, Yasushi, Yoshida, Mari, Murayama, Shigeo, Mishima, Kenichi, Nishida, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884914/
https://ncbi.nlm.nih.gov/pubmed/28550528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0624-1
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