Inhaled, Nebulized Sodium Nitrite Protects In Murine and Porcine Experimental Models Of Hemorrhagic Shock and Resuscitation by Limiting Mitochondrial Injury

OBJECTIVE: The cellular injury that occurs in the setting of hemorrhagic shock and resuscitation (HS/R) affects all tissue types and can drive altered inflammatory responses. Resuscitative adjuncts hold the promise of decreasing such injury. Here we test the hypothesis that sodium nitrite (NaNO(2)),...

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Bibliographic Details
Published in:Nitric Oxide
Main Authors: Kautza, Benjamin, Gomez, Hernando, Escobar, Daniel, Corey, Catherine, Ataya, Bilal, Luciano, Jason, Botero, Ana Maria, Gordon, Lisa, Brumfield, John, Martinez, Silvia, Holder, Andre, Ogundele, Olufunmilayo, Pinsky, Michael, Shiva, Sruti, Zuckerbraun, Brian S.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884699/
https://ncbi.nlm.nih.gov/pubmed/26410351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2015.09.006
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