Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects

INTRODUCTION: The efficacy of nebulized sodium nitrite (AIR001) has been demonstrated in animal models of pulmonary arterial hypertension (PAH), but it was not known if inhaled nitrite would be well tolerated in human subjects at exposure levels associated with efficacy in these models. METHODS: Inh...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Rix, Peter J., Vick, Andrew, Attkins, Neil J., Barker, Geoffrey E., Bott, Adrian W., Alcorn, Harry, Gladwin, Mark T., Shiva, Sruti, Bradley, Stephen, Hussaini, Azra, Hoye, William L., Parsley, Ed L., Masamune, Hiroko
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2014
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335132/
https://ncbi.nlm.nih.gov/pubmed/25421879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0201-y
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