Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell–Derived Ventricular Cardiomyocytes and Engineered 3-Dimensional Tissue Constructs

BACKGROUND: Human (h) embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) serve as a potential unlimited ex vivo source of cardiomyocytes (CMs). However, a well-accepted roadblock has been their immature phenotype. hESC/iPSC-derived ventricular (v) CMs and their engineered cardiac...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Chen, Gaopeng, Li, Sen, Karakikes, Ioannis, Ren, Lihuan, Chow, Maggie Zi-Ying, Chopra, Anant, Keung, Wendy, Yan, Bin, Chan, Camie W.Y., Costa, Kevin D., Kong, Chi-Wing, Hajjar, Roger J., Chen, Christopher S., Li, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884688/
https://ncbi.nlm.nih.gov/pubmed/25504561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.114.002049
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