Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial K(ATP) channels

Human embryonic stem cells (hESCs) is a potential unlimited ex vivo source of ventricular (V) cardiomyocytes (CMs), but hESC-VCMs and their engineered tissues display immature traits. In adult VCMs, sarcolemmal (sarc) and mitochondrial (mito) ATP-sensitive potassium (K(ATP)) channels play crucial ro...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Keung, Wendy, Ren, Lihuan, Sen Li, Wong, Andy On-Tik, Chopra, Anant, Kong, Chi-Wing, Tomaselli, Gordon F., Chen, Christopher S., Li, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039730/
https://ncbi.nlm.nih.gov/pubmed/27677332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34154
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