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Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin

Previous studies utilizing PUGNAc, the most widely used β-N-acetylglucosaminidase (OGA) inhibitor to increase global O-N-acetylglucosamine (GlcNAc) levels, have reported a variety of effects including insulin resistance as a direct result of elevated O-GlcNAc levels. The notion of OGA inhibition cau...

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Detalhes bibliográficos
Publicado no:Glycobiology
Main Authors: Teo, Chin Fen, El-Karim, Enas Gad, Wells, Lance
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884396/
https://ncbi.nlm.nih.gov/pubmed/27072814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww043
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