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Accurate PDZ/Peptide Binding Specificity with Additive and Polarizable Free Energy Simulations
PDZ domains contain 80–100 amino acids and bind short C-terminal sequences of target proteins. Their specificity is essential for cellular signaling pathways. We studied the binding of the Tiam1 PDZ domain to peptides derived from the C-termini of its Syndecan-1 and Caspr4 targets. We used free ener...
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| Publicado no: | Biophys J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5883551/ https://ncbi.nlm.nih.gov/pubmed/29539396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.01.008 |
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