Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in animal models, but randomized controlled trials fai...

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Publicat a:Sci Rep
Autors principals: Liu, Yang, Pejchinovski, Martin, Wang, Xueqi, Fu, Xuebin, Castelletti, Deborah, Watnick, Terry J., Arcaro, Alexandre, Siwy, Justyna, Mullen, William, Mischak, Harald, Serra, Andreas L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882886/
https://ncbi.nlm.nih.gov/pubmed/29615724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22938-x
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