Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in animal models, but randomized controlled trials fai...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Yang, Pejchinovski, Martin, Wang, Xueqi, Fu, Xuebin, Castelletti, Deborah, Watnick, Terry J., Arcaro, Alexandre, Siwy, Justyna, Mullen, William, Mischak, Harald, Serra, Andreas L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882886/
https://ncbi.nlm.nih.gov/pubmed/29615724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22938-x
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